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Liste des publications

Lacroix M, Rodier G, Kirsh O, Houles T, Delpech H, Seyran B, Gayte L, Casas F, Pessemesse L, Heuillet M, Bellvert F, Portais JC, Berthet C, Bernex F, Brivet M, Boutron A, Le Cam L, Sardet C. E4F1 controls a transcriptional program essential for pyruvate dehydrogenase activity. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10998-1003. doi: 10.1073/pnas.1602754113. Epub 2016 Sep 12.

 

Goguet-Rubio P, Seyran B, Gayte L, Bernex F, Sutter A, Delpech H, Linares LK, Riscal R, Repond C, Rodier G, Kirsh O, Touhami J, Noel J, Vincent C, Pirot N, Pavlovic G, Herault Y, Sitbon M, Pellerin L, Sardet C, Lacroix M, Le Cam L. E4F1-mediated control of pyruvate dehydrogenase activity is essential for skin homeostasis. Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):11004-9. doi: 10.1073/pnas.1602751113. Epub 2016 Sep 12.

 

Arena G, Valente EM. PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease. J Pathol. 2016 Oct 4. doi: 10.1002/path.4815. [Epub ahead of print]

 

Riscal R, Schrepfer E, Arena G, Cissé MY, Bellvert F, Heuillet M, Rambow F, Bonneil E, Sabourdy F, Vincent C, Ait-Arsa I, Levade T, Thibaut P, Marine JC, Portais JC, Sarry JE, Le Cam L, Linares LK. Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. Molecular-Cell, fulltext, S 1097-2765(16)30109-5

 

Boutzen H, Saland E, Larrue C, de Toni F, Gales L, Castelli FA, Cathebas M, Zaghdoudi S, Stuani L, Kaoma T, Riscal R, Yang G, Hirsch P, David M, De Mas-Mansat V, Delabesse E, Vallar L, Delhommeau F, Jouanin I, Ouerfelli O, Le Cam L, Linares LK, Junot C, Portais JC, Vergez F, Récher C, Sarry JE. Isocitrate dehydrogenase 1 mutations prime the all-trans retinoic acid myeloid differentiation pathway in acute myeloid leukemia.  J Exp Med. 2016 Apr 4;213(4):483-97. Epub 2016 Mar 7. 

 

Le Roux I, Konge J, Le Cam L, Flamant P, Tajbakhsh S. Numb is required to prevent p53-dependent senescence following skeletal muscle injury. Nat Commun. 2015 Oct 27;6:8528.

 

Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E. Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.
Oncotarget. 2015 Sep 29;6(29) : 28084-103.

 

Houlès T, Rodier G, Le Cam L, Sardet C, Kirsh O. Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs.
Genom Data. 2015 Jul 14;5:368-70.  eCollection 2015 Sep.

 

Garcin G, Guiraud I, Lacroix M, Genthon C, Rialle S, Joujoux JM, Meunier L, Lavabre-Bertrand T, Stoebner PE, Gallic LL. AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin. J Invest Dermatol. 2015 Jul 15. doi: 10.1038/jid.2015.282. [Epub ahead of print]

 

Rodier G, Kirsh O, Baraibar M, Houlès T, Lacroix M, Delpech H, Hatchi E, Arnould S, Severac D, Dubois E, Caramel J, Julien E, Friguet B, Le Cam L, Sardet C.
The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions. Cell Rep. 2015 Apr 14;11(2):220-33. doi: 10.1016/j. celrep.2015.03.024. Epub 2015 Apr 2.

 

Lacroix M, Linares LK, Le Cam L. Role of the p53 tumor suppressor in metabolism. Med Sci (Paris). 2013 Dec;29(12):1125-30. doi: 10.1051/ medsci/20132912016. Epub 2013 Dec 20

 

Hatchi E, Rodier G, Sardet C, Le Cam L. E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells. Autophagy. 2011 Dec 1;7(12):1566-7.

 

Hatchi E, Rodier G, Lacroix M, Caramel J, Kirsh O, Jacquet C, Schrepfer E, Lagarrigue S, Linares LK, Lledo G, Tondeur S, Dubus P, Sardet C, Le Cam L. E4F1 deficiency results in oxidative stress–mediated cell death of leukemic cells.  J Exp Med. 2011 Jul 4;208(7):1403-17

Caramel J, Lacroix M, Le Cam L, Sardet C. E4F1 connects the Bmi1-ARF-p53 pathway to epidermal stem cell-dependent skin homeostasis. Cell Cycle. 2011 Mar 15;10(6):866-7. Epub 2011 Mar 15.

 

Lacroix M, Caramel J, Goguet-Rubio P, Linares LK, Estrach S, Hatchi E, Rodier G, Lledo G, de Bettignies C, Thépot A, Deraison C, Chébli K, Hovnanian A, Hainaut P, Dubus P, Sardet C, Le Cam L. Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21076-8

 

Laëtitia K. Linares, Rosemary Kiernan, Robinson Triboulet, Christine Chable-Bessia, Daniel Latreille, Olivier Cuvier, Matthieu Lacroix, Laurent Le Cam, Olivier Coux, and Monsef Benkirane. (2006). Intrinsic ubiquitylation activity of PCAF controls the stability of the oncoprotein Hdm2. Nat Cell Biol. 2007 Mar; 9(3):331-8.

 

Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C. (2006). E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation. Cell. Nov17;127(4):775-88.

 

Paul C, Lacroix M, Iankova I, Julien E, Schafer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C. (2006). The LIM-only protein FHL2 is a negative regulator of E4F1. Oncogene. 2006 Sep 7;25(40):5475-84.

 

Le Cam L, Lacroix M, Ciemerych MA, Sardet C, Sicinski P. (2004)
The E4F protein is required for mitotic progression during embryonic cell cycles. Mol Cell Biol. 24(14):6467-75.

Sicinska E, Aifantis I, Le Cam L., Swat W, Borowski C, Yu Q, Ferrando AA, Levin SD, Geng Y, von Boehmer H, Sicinski P. (2003) Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell. Dec;4(6):451-61.

 

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