Research
Tumor microenvironnement and resistance to treatment : A. Turtoi

Suzuki M, Yokobori T, Gombodorj N, Yashiro M, Turtoi A, Handa T, Ogata K, Oyama T, Shirabe K, Kuwano H. High stromal transforming growth factor β-induced expression is a novel marker of progression and poor prognosis in gastric cancer. J Surg Oncol. 2018; 118 (6): 966-974.

https://www.ncbi.nlm.nih.gov/pubmed/30260476

Blomme A, Van Simaeys G, Doumont G, Costanza B, Bellier J, Otaka Y, Sherer F, Lovinfosse P, Boutry S, Palacios AP, De Pauw E, Hirano T, Yokobori T, Hustinx R, Bellahcène A, Delvenne P, Detry O, Goldman S, Nishiyama M, Castronovo V, Turtoi A. preclinical model stroma adopts a human-like metabolic phenotype in the PDX model of colorectal cancer and liver metastases. Oncogene. 2018; 37 (9): 1237-1250. https://www.ncbi.nlm.nih.gov/pubmed/29242606

Costanza B*, Turtoi A*, Bellahcène A, Hirano T, Peulen O, Blomme A, Hennequière V, Mutijima E, Boniver J, Meuwis MA, Josse C, Koopmansch B, Segers K, Yokobori T, Fahmy K, Thiry M, Coimbra C, Garbacki N, Colige A, Baiwir D, Bours V, Louis E, Detry O, Delvenne P, Nishiyama M, Castronovo V. Innovative methodology for the identification of soluble biomarkers in fresh tissues. Oncotarget. 2018; 9 (12): 10665-10680.

https://www.ncbi.nlm.nih.gov/pubmed/29535834

Ronca R, Van Ginderachter JA, Turtoi A. Paracrine interactions of cancer-associated fibroblasts, macrophages and endothelial cells: tumor allies and foes. Curr Opin Oncol. 2018; 30 (1): 45-53.

https://www.ncbi.nlm.nih.gov/pubmed/29084000

Blomme A, Costanza B, de Tullio P, Thiry M, Van Simaeys G, Boutry S, Doumont G, Di Valentin E, Hirano T, Yokobori T, Gofflot S, Peulen O, Bellahcène A, Sherer F, Le Goff C, Cavalier E, Mouithys-Mickalad A, Jouret F, Cusumano PG, Lifrange E, Muller RN, Goldman S, Delvenne P, De Pauw E, Nishiyama M, Castronovo V, Turtoi A. Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer. Oncogene. 2017; 36 (15): 2116-2130.

https://www.ncbi.nlm.nih.gov/pubmed/27775075

Chiavarina B, Nokin MJ, Bellier J, Durieux F, Bletard N, Sherer F, Lovinfosse P, Peulen O, Verset L, Dehon R, Demetter P, Turtoi A, Uchida K, Goldman S, Hustinx R, Delvenne P, Castronovo V, Bellahcène A. Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer. Int J Mol Sci. 2017; 18 (1). pii: E213.

https://www.ncbi.nlm.nih.gov/pubmed/28117708

Costanza B, Umelo IA, Bellier J, Castronovo V, Turtoi A. Stromal Modulators of TGF-β in Cancer. J Clin Med. 2017; 6 (1). pii: E7.

https://www.ncbi.nlm.nih.gov/pubmed/28067804

Chiavarina B, Turtoi A. Collaborative and Defensive Fibroblasts in Tumor Progression and Therapy Resistance. Curr Med Chem. 2017; 24 (26): 2846-2859.

https://www.ncbi.nlm.nih.gov/pubmed/28462708

Blomme A, Fahmy K, Peulen O, Costanza B, Fontaine M, Struman I, Baiwir D, De Pauw E, Thiry M, Bellahcène A, Castronovo V, Turtoi A. 2016. Myoferlin is a novel exosomal protein and functional regulator of cancer-derived exosomes. Oncotarget. doi: 10.18632/oncotarget.13276.

https://www.ncbi.nlm.nih.gov/pubmed/27845903

Blomme A, Cusumano P, Peulen O, Bellahcène A, Castronovo V, Turtoi A. 2016. Asporin The Protective Wall Against Triple Negative Breast Cancer. Med Sci (Paris). doi: 10.1051/medsci/20163211020.

https://www.ncbi.nlm.nih.gov/pubmed/28008845

Nokin MJ, Durieux F, Peixoto P, Chiavarina B, Peulen O, Blomme A, Turtoi A, Costanza B, Smargiasso N, Baiwir D, Scheijen JL, Schalkwijk CG, Leenders J, De Tullio P, Bianchi E, Thiry M, Uchida K, Spiegel DA, Cochrane JR, Hutton CA, De Pauw E, Delvenne P, Belpomme D, Castronovo V, Bellahcène A. 2016. Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis. Elife. doi: 10.7554/eLife.19375.

https://www.ncbi.nlm.nih.gov/pubmed/27759563

Henry A, Nokin MJ, Leroi N, Lallemand F, Lambert J, Goffart N, Roncarati P, Bianchi E, Peixoto P, Blomme A, Turtoi A, Peulen O, Habraken Y, Scholtes F, Martinive P, Delvenne P, Rogister B, Castronovo V, Bellahcène A. 2016. New role of osteopontin in DNA repair and impact on human glioblastoma radiosensitivity. Oncotarget. 35(34): 4481-94.

https://www.ncbi.nlm.nih.gov/pubmed/27563812

Peixoto P, Blomme A, Ronca R, Rezzola S, Palacios AP, Schoysman L, Boutry S, Goffart N, Peulen O, Maris P, Di Valentin E, Hennequière V, Bianchi E, Costanza B, Henry A, Rogister B, Muller R, Delvenne P, Bellahcene A, Castronovo V, Turtoi A. 2015. HDAC7 resets STAT3 tumorigenic activity in human glioblastoma independently of EGFR and PTEN status: new opportunities for selected targeted therapies. Oncogene. 35 (34): 4481-94.

https://www.ncbi.nlm.nih.gov/pubmed/26853466

Maris P, Blomme A, Perez Palacios A, Costanza B, Bellahcène A, Bianchi E, Gofflot S, Drion P, Elvi Trombino G, Di Valentin E, Cusumano P, Maweja S, Jerusalem G, Delvenne P, Lifrange E, Castronovo V, Turtoi A. 2015. Asporin is a fibroblast-derived TGF-ß inhibitor and a tumor suppressor associated with good prognosis in breast cancer. PLOS Medicine. 12(9): e1001871.

https://www.ncbi.nlm.nih.gov/pubmed/26327350

Fahmy K, Gonzalez A, Arafa M, Peixoto P, Bellahcène A, Turtoi A, Delvenne P, Thiry M, Castronovo V, Peulen O. 2015. Myoferlin plays a key role in VEGFA secretion and impacts tumor-associated angiogenesis in human pancreas cancer. Int J Cancer. doi: 10.1002/ijc.29820.

https://www.ncbi.nlm.nih.gov/pubmed/26311411

Lamour V, Henry A, Kroonen J, Nokin MJ, von Marschall Z, Fisher LW, Chau TL, Chariot A, Sanson M, Delattre JY, Turtoi A, Peulen O, Rogister B, Castronovo V, Bellahcène A. 2015. Targeting osteopontin suppresses glioblastoma stem-like cell character and tumorigenicity in vivo. Int J Cancer. doi: 10.1002/ijc.29454.

https://www.ncbi.nlm.nih.gov/pubmed/25620078

Turtoi A, Blomme A, Castronovo V. 2015. Intratumoral heterogeneity and consequences for targeted therapies. Bull Cancer. 102(1):17-23.

https://www.ncbi.nlm.nih.gov/pubmed/25609489

Turtoi A, Peixoto P, Castronovo V. Bellahcène A. 2015. Histone Deacetylases and Cancer-Associated Angiogenesis: Current Understanding of the Biology and Clinical Perspectives. Crit Rev Oncog. 20(1-2):119-37.

https://www.ncbi.nlm.nih.gov/pubmed/25746107

Chiavarina B, Nokin MJ, Durieux F, Bianchi E, Turtoi A, Peulen O, Peixoto P, Irigaray P, Uchida K, Belpomme D, Delvenne P, Castronovo V, Bellahcène A. 2014. Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes. Oncotarget. 5 (14): 5472-82.

https://www.ncbi.nlm.nih.gov/pubmed/24978626

Turtoi A, Blomme A, Bianchi E, Maris P, Vannozzi R, Naccarato AG, Delvenne P, De Pauw E, Bevilacqua G, Castronovo V. 2014. Accessibilome of Human Glioblastoma: Collagen-VI-alpha-1 Is a New Target and a Marker of Poor Outcome. J Proteome Res. 13(12): 5660-9.

https://www.ncbi.nlm.nih.gov/pubmed/25325876

Turtoi A, Blomme A, Debois D, Somja J, Delvaux D, Patsos G, Di Valentin E, Peulen O, Mutijima EN, De Pauw E, Delvenne P, Detry O, Castronovo V. 2014. Organized proteomic heterogeneity in colorectal cancer liver metastases and implications for therapies. Hepatology. 59 (3): 924-34.

https://www.ncbi.nlm.nih.gov/pubmed/23832580

Turtoi A, Blomme A, Bellahcène A, Gilles C, Hennequière V, Peixoto P, Bianchi E, Noel A, De Pauw E, Lifrange E, Delvenne P, Castronovo V. 2013. Myoferlin Is a Key Regulator of EGFR Activity in Breast Cancer. Cancer Res. 73 (17): 5438-48.

https://www.ncbi.nlm.nih.gov/pubmed/23864327

Warnock G*, Turtoi A*, Blomme A, Bretin F, Bahri MA, Lemaire C, Libert LC, Seret AE, Luxen A, Castronovo V, Plenevaux AR. 2013. In Vivo PET/CT in a Human Glioblastoma Chicken Chorioallantoic Membrane Model: A New Tool for Oncology and Radiotracer Development. J Nucl Med. 54 (10):1782-8. (*equal contribution).

https://www.ncbi.nlm.nih.gov/pubmed/23970367

Peulen O, Gonzalez A, Peixoto P, Turtoi A, Mottet D, Delvenne P, Castronovo V. 2013. The anti-tumor effect of HDAC inhibition in a human pancreas cancer model is significantly improved by the simultaneous inhibition of cyclooxygenase 2. PLoS One. 8 (9): e75102.

https://www.ncbi.nlm.nih.gov/pubmed/24040391

Fradet A, Sorel H, Depalle B, Serre CM, Farlay D, Turtoi A, Bellahcene A, Follet H, Castronovo V, Clézardin P, Bonnelye E. 2013. A new preclinical model model of osteoblastic/osteolytic lesions from human androgen-resistant prostate cancer. PLoS One. 8 (9): e75092.

https://www.ncbi.nlm.nih.gov/pubmed/24069383

Calligaris D, Longuespée R, Debois D, Asakawa D, Turtoi A, Castronovo V, Noël A, Bertrand V, De Pauw-Gillet MC, De Pauw E. 2013. Selected Protein Monitoring in Histological Sections by Targeted MALDI-FTICR In-Source Decay Imaging. Anal Chem. 85 (4): 2117-26.

https://www.ncbi.nlm.nih.gov/pubmed/23323725

Dobson R, Collodoro M, Gilles N, Turtoi A, De Pauw E, Quinton L. 2012. Secretion and maturation of conotoxins in the venom ducts of Conus textile. Toxicon. 60 (8):1370-9.

https://www.ncbi.nlm.nih.gov/pubmed/23031820

Turtoi A, Musmeci D, Naccarato AG, Scatena C, Ortenzi V, Kiss R, Murtas D, Patsos G, Mazzucchelli G, De Pauw E, Bevilacqua G, Castronovo V. 2012. Sparc-Like Protein 1 is a New Marker of Human Glioma Progression. J Proteome Res. 11 (10): 5011-21.

https://www.ncbi.nlm.nih.gov/pubmed/22909274

Turtoi A, Denis M, Matheus N, Dumont B, Peixoto P, Hennequière V, Deroanne C, Colige A, De Pauw E, Bellahcène A and Castronovo V. 2012. The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells. Angiogenesis. 15 (4): 543-54.

https://www.ncbi.nlm.nih.gov/pubmed/22584896

Dumont B, Castronovo V, Peulen O, Blétard N, Clézardin P, Delvenne P, De Pauw E, Turtoi* A and Bellahcène* A. 2012. Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis. Journal of Proteome Research 11 (4): 2247-60. (*equal contribution).

https://www.ncbi.nlm.nih.gov/pubmed/22356681

Turtoi A, Castronovo V. 2012. Isotopically labeled proteome as an internal standard for multiple reaction monitoring-based biomarker quantification. Expert Rev Proteomics 9 (3): 245-8.

https://www.ncbi.nlm.nih.gov/pubmed/22809204

Turtoi A, Musmeci D, Wang YH, Dumont B, Somja J, Bevilacqua G, De Pauw E, Delvenne P, Castronovo V. 2011. Identification of novel accessible proteins bearing diagnostic and therapeutic potential in human pancreatic ductal adenocarcinoma. Journal of Proteome Research 10 (9): 4302-13.

https://www.ncbi.nlm.nih.gov/pubmed/21755970

Turtoi A, Dumont B, Greffe Y, Blomme A, Mazzucchelli G, Delvenne P, Mutijima EN, Lifrange E, De Pauw E, Castronovo V. 2011. Novel Comprehensive Approach for Accessible Biomarker Identification and Absolute Quantification from Precious Human Tissues. Journal of Proteome Research 10 (7): 3160-3182.

https://www.ncbi.nlm.nih.gov/pubmed/21534635

Turtoi A, De Pauw E, Castronovo V. 2011. Innovative proteomics for the discovery of systemically accessible cancer biomarkers suitable for imaging and targeted therapies. American Journal of Pathology 178 (1): 12-18.

https://www.ncbi.nlm.nih.gov/pubmed/21224037

Kischel P, Waltregny D, Dumont B, Turtoi A, Greffe Y, Kirsch S, De Pauw E and Castronovo V. 2010. Versican overexpression in human breast cancer lesions: known and new isoforms for stromal tumor targeting. International Journal of Cancer 26 (3):640-50.

https://www.ncbi.nlm.nih.gov/pubmed/19662655

Castronovo V, Waltregny D, Detry O, Coimbra Marques C, De Roover A, Honoré P, De Pauw E, Turtoi A. 2010. Targeted therapy: toward a clean and effective war against cancer. Revue Medicale de Liege 64 Spec No: 20-3. French.

https://www.ncbi.nlm.nih.gov/pubmed/20085011

Fleron M, Greffe Y, Musmeci D, Massart AC, Hennequiere V, Mazzucchelli G, Waltregny D, De Pauw-Gillet MC, Castronovo V, De Pauw E, Turtoi A. 2010. Novel post-digest isotope coded protein labeling method for phospho- and glycoproteome analysis. Journal of Proteomics 73 (10): 1986-2005.

https://www.ncbi.nlm.nih.gov/pubmed/20601274

Turtoi A, Mazzucchelli G, De Pauw E. 2010. Isotope Coded Protein Label Quantification of Serum Proteins – Comparison with the Label Free LC-MS and Validation Using the MRM Approach. Talanta. 80 (4): 1487-95.

https://www.ncbi.nlm.nih.gov/pubmed/20082806

Turtoi A, Sharan R, Srivastava A, Schneeweiss FHA. 2010. Proteomic and genomic modulations induced by γ-irradiation of human blood lymphocytes. International Journal of Radiation Biology. 86 (10): 888-904.

https://www.ncbi.nlm.nih.gov/pubmed/20653344

Turtoi A, Brown I, Schläger M, Schneeweiss FHA. 2010. Gene Expression Profile of Human Lymphocytes Exposed to 211At α-Particles. Radiation Research. 174 (2): 125-36.

https://www.ncbi.nlm.nih.gov/pubmed/20681779

Turtoi A, Schneeweiss FHA. 2009. Acute expression response of specific radiation sensitive genes in human lymphocytes following exposure to ²¹¹At α-particles. International Journal of Radiation Biology. 85 (5): 403-12.

https://www.ncbi.nlm.nih.gov/pubmed/19382019

Turtoi A, Brown I, Oskamp D, Schneeweiss FHA. 2008. Early Gene Expression in Human Lymphocytes after γ-Radiation – A Genetic Pattern with Potential for Biodosimetry. International Journal of Radiation Biology. 84 (5): 375-387.

https://www.ncbi.nlm.nih.gov/pubmed/18464067

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