Francais

Summary

Hormone signaling and cancer

Team Leader : Vincent Cavaillès
 
Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5
Tél. 33 (0)4 67 61 24 05
Tél/Sec. 33 (0)4 67 61 85 77
Fax. 33 (0)4 67 61 37 87
vincent.cavailles@inserm.fr
 
Research topics

 

The main scientific objective of the team is to decipher the transcriptional networks controlling the expression of key genes involved in the control of cellular homeostasis and to understand how their alterations contribute to the formation and progression of cancer.


We focus our research on the RIP140 and LCoR transcriptional coregulators initially identified as key players in nuclear receptor signaling. We have characterized the role of RIP140 on other signaling pathways and its relevance in physiopathology. We have demonstrated that RIP140 targets other important pathways such as the E2F/Rb pathway. Our recent data show that RIP140 inhibits the Wnt/βcatenin signaling and controls the differentiation, proliferation and turnover of the intestinal epithelium by regulating the expression and activity of different transcription factors. We are currently exploring the physiological functions of RIP140 and its role in gastrointestinal tumorigenesis. In particular, we study the involvement of RIP140 in the control of DNA repair and in the metabolism of cancer cells as well as its role in the expression and activity of p53. The impact of RIP140 in regulating the phenotype of cancer stem cells is also investigated.


more informations ...

 
Main Publications
 

Vattai A, Cavailles V, Sixou S, Beyer S, Kuhn C, Peryanova M, Heidegger H,Hermelink K, Mayr D, Mahner S, Dannecker C, Jeschke U, Kost B. Investigation of RIP140 and LCoR as independent markers for poor prognosis in cervical cancer.
Oncotarget. 2017 Oct 31;8(62): 105356-105371.

 

Voisin M, de Medina P, Mallinger A, Dalenc F, Huc-Claustre E, Leignadier J, Serhan N, Soules R, Ségala G, Mougel A, Noguer E, Mhamdi L, Bacquié E, Iuliano L, Zerbinati C, Lacroix-Triki M, Chaltiel L, Filleron T, Cavaillès V, Al Saati T, Rochaix P, Duprez-Paumier R, Franchet C, Ligat L, Lopez F, Record M, Poirot M, Silvente-Poirot S. Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor. Proc Natl Acad Sci U S A. 2017 Oct 31;114 (44):E9346-E9355.

 

Nagarajan S, Belaid H, Pochat-Bohatier C, Teyssier C, Iatsunskyi I, Coy E, Balme S, Cornu D, Miele P, Kalkura NS, Cavailles V, Bechelany M. Design of Boron Nitride/Gelatin Electrospun Nanofibers for Bone Tissue Engineering. ACS Appl Mater Interfaces. 2017 Sep 11. doi: 10.1021 /acsami.7b13199. [Epub ahead of print]

 

Triki M, Lapierre M, Cavailles V, Mokdad-Gargouri R. Expression and role of nuclear receptor coregulators in colorectal cancer. World J Gastroenterol. 2017 Jul 7;23(25) :4480-4490. doi: 10.3748/wjg. v23. i25.4480. Review.

 

Jalaguier S, Teyssier C, Nait Achour T, Lucas A, Bonnet S, Rodriguez C, Elarouci N, Lapierre M, Cavaillès V. Complex regulation of LCoR signaling in breast cancer cells. Oncogene. 2017 Apr 17. doi: 10.1038/onc.2017.97.

 

more informations ...

 

© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Sign in - Conception : ID Alizés