Research
Nuclear signaling and cancer : V. Cavaillès

The main scientific objective of the "Nuclear Signaling and Cancer" team is to decipher the transcriptional networks controlling the expression of key genes involved in the control of cell homeostasis and to understand how their deregulation contributes to cancer formation and progression. Our work focuses on the transcriptional coregulators RIP140 and LCoR and on their action in different oncogenic signaling pathways including nuclear receptors. We are also studying the peptidyl deiminase PADIs, their role in arginine citrullination, in the control of genome organization and tumorigenesis, and the potential implication in therapeutic strategies. In parallel, we are developing a more applied research in collaboration with chemists, aimed at developing new biomaterials for the treatment of bone metastases of breast cancer. The expected results are 1) a better understanding of the molecular mechanisms of tumorigenesis and of the resistance of cancers to treatment, 2) the identification of new diagnostic and/or prognostic markers and new medical devices or therapeutic approaches to improve the management of gastrointestinal and gynecological cancers. 

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