The main scientific objective of the team is to decipher the transcriptional networks controlling the expression of key genes involved in the control of cellular homeostasis and to understand how their alterations contribute to the formation and progression of cancer. Our work is mainly focused on nuclear receptors and transcription coregulators including RIP140 and LCoR. In parallel, we develop a more applied research and have set up a technical platform for the generation and use of bioluminescent cell lines to characterize endocrine disruptors. We have also recently established a fruitful collaboration with chemists to generate new biomaterials for therapeutic applications.
The expected results are a better understanding of the molecular mechanisms of cancer resistance to therapy and the identification of new diagnostic and/or prognostic markers for the management of gastrointestinal and gynecological cancers. Our work may also lead to the identification of new combinations of therapeutic agents for better efficacy of inhibition of cancer growth. Finally, it also help to identify combinations of environmental molecules able to participate actively in the carcinogenesis process with obvious consequences for the prevention of carcinogenic risks.
Jalaguier S, Teyssier C, Nait Achour T, Lucas A, Bonnet S, Rodriguez C, Elarouci N, Lapierre M, Cavaillès V. Complex regulation of LCoR signaling in breast cancer cells. Oncogene. 2017 Aug 17;36(33):4790-4801.
Lapierre M, Linares A, Dalvai M, Duraffourd C, Bonnet S, Boulahtouf A,
Rodriguez C, Jalaguier S, Assou S, Orsetti B, Balaguer P, Maudelonde T, Blache P, Bystricky K, Boulle N, Cavaillès V. Histone deacetylase 9 regulates breast cancer cell proliferation and the response to histone deacetylase inhibitors. Oncotarget. 2016 Apr 12;7(15):19693-708.
Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds. Nat Commun. 2015 Sep 3;6:8089.
Lapierre M, Bonnet S, Bascoul-Mollevi C, Ait-Arsa I, Jalaguier S, Del Rio M, Plateroti M, Roepman P, Ychou M, Pannequin J, Hollande F, Parker M, Cavailles V. RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest. 2014 May;124(5):1899-913.