Research
Molecular oncogenesis : L. Le Cam

activities

Our laboratory is interested in understanding how the p53 pathway, the most commonly deregulated tumor suppressor pathway in human cancers, regulates metabolism.

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Main Publications

Lahalle A, Lacroix M, De Blasio C, Cissé M, Linares L, Le Cam L The p53 Pathway and Metabolism: The Tree That Hides the Forest. Cancers. 2021;13(1):133. doi:10.3390/cancers13010133

Cissé M, Pyrdziak S, Firmin N, Gayte L, Heuillet M, Bellvert F, Fuentes M, Delpech H, Riscal R, Arena G, Chibon F, Le Gellec S, Maran-Gonzalez A, Chateau M-C, Theillet C, Portais J-C, Le Cam L, Linares L Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma. Sci. Transl. Med.. 2020;12(547):eaay2163. doi:10.1126/scitranslmed.aay2163

Arena G, Cissé M, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold J, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Marine J-C, Etienne-Manneville S, Bernex F, Lombčs A, Cameron C, Dubouchaud H, Ricchetti M, Linares L, Le Cam L Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53. Mol. Cell. 2018;69(4):594-609.e8. doi:10.1016/j.molcel.2018.01.023

Riscal R, Schrepfer E, Arena G, Cisse M, Bellvert F, Heuillet M, Rambow F, Bonneil E, Sabourdy F, Vincent C, Ait-Arsa I, Levade T, Thibaut P, Marine J, Portais J, Sarry J, Le Cam L, Linares L Chromatin-Bound MDM2 Regulates Serine Metabolism and Redox Homeostasis Independently of p53. Molecular cell. May 31 2016. doi:10.1016/j.molcel.2016.04.033

Rodier G, Kirsh O, Baraibar M, Houles T, Lacroix M, Delpech H, Hatchi E, Arnould S, Severac D, Dubois E, Caramel J, Julien E, Friguet B, Le Cam L, Sardet C The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions. Cell reports. 2015;11. doi:10.1016/j.celrep.2015.03.024


team

Team Leader : Laurent Le Cam
 

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle

34298 Montpellier cedex 5

 

Tél. 33 (0)4 11 28 31 43
laurent.lecam@inserm.fr

partners / funding

         


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés