Research
Epigenetic, cell differentiation and cancer : F. Cammas

Epigenetic, cell differentiation and cancer

Team Leader : Florence Cammas
 
Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5

 
Tél. : 33 (0)4 67 61 24 21
Fax : 33 (0)4 67 61 37 87
florence.cammas@inserm.fr
 
Research topics

 

Functions of heterochromatin in preventing hepatic tumorigenesis : functional and molecular characterization of HP1 proteins

We recently demonstrated that the hepatocyte-specific inactivation of HP1 proteins in mice lead to to tumour development in most animals. We further showed that the loss of HP1 was associated with the loss of most heterochromatin hallmarks, with altered expression of many genes known to be essential for liver homeostasis and with reactivation of specific retrotransposons. Our present projects are now aimed at understanding the inter-relationship between all these events underlying the anti-tumorigenic function of HP1 proteins in liver in order to be able to propose therapeutic strategies based on these observations. Through the analysis of the different animal and cellular models lacking one or several members of the HP1 family that we have established in the lab, we are particularly interested in analyzing the impact of heterochromatin on the three dimensional organization of the nucleus, on the expression and replication of the genome with a special focus on putative mutagenic sequences such as the retrotransposons.


 
 
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Main Publications

 

Fasching L, Kapopoulou A, Sachdeva R, Petri R, Jönsson ME, Männe C, Turelli P, Jern P, Cammas F, Trono D, Jakobsson J. TRIM28 represses transcription of endogenous retroviruses in neural progenitor cells. Cell Rep. 2015 Jan 6;10(1):20-8. doi: 10.1016/j. celrep .2014.12.004. Epub 2014 Dec 24.

 

Paul C, Sardet C, Fabbrizio E. The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion. Biol Open. 2015 Feb 13;4(3):312-6. doi: 10.1242/bio. 201411247.

 

Harouz H, Rachez C, Meijer BM, Marteyn B, Donnadieu F, Cammas F, Muchardt C, Sansonetti P, Arbibe L. Shigella flexneri targets the HP1γ subcode through the phosphothreonine lyase OspF. EMBO J. 2014 Sep 12. pii: e201489244. [Epub ahead of print]

 

Herquel B, Ouararhni K, Martianov I, Le Gras S, Ye T, Keime C, Lerouge T, Jost B, Cammas F, Losson R, Davidson I. Trim24-repressed VL30 retrotransposons regulate gene expression by producing noncoding RNA. Nat Struct Mol Biol. 2013 Feb 3;20(3):339-46. doi: 10. 10 38 /n s m b.2496. Epub 2013 Feb 3.

 

Allan RS, Zueva E, Cammas F, Schreiber HA, Masson V, Belz GT, Roche D, Maison C, Quivy JP, Almouzni G, Amigorena S. An epigenetic silencing pathway controlling T helper 2 cell lineage commitment. Nature. 2012 Jul 12;487(7406):249-53


more information ...

 

Sommaire

Functions of heterochromatin in preventing hepatic tumorigenesis : functional and molecular characterization of HP1 proteins

We recently demonstrated that the hepatocyte-specific inactivation of HP1 proteins in mice lead to to tumour development in most animals. We further showed that the loss of HP1 was associated with the loss of most heterochromatin hallmarks, with altered expression of many genes known to be essential for liver homeostasis and with reactivation of specific retrotransposons. Our present projects are now aimed at understanding the inter-relationship between all these events underlying the anti-tumorigenic function of HP1 proteins in liver in order to be able to propose therapeutic strategies based on these observations. Through the analysis of the different animal and cellular models lacking one or several members of the HP1 family that we have established in the lab, we are particularly interested in analyzing the impact of heterochromatin on the three dimensional organization of the nucleus, on the expression and replication of the genome with a special focus on putative mutagenic sequences such as the retrotransposons.

Principales Publications


Equipe

Team Leader : Florence Cammas
 

Institut de Recherche en
Cancérologie de Montpellier
Campus Val d’Aurelle
34298 Montpellier cedex 5


 

Tél. : 33 (0)4 67 61 24 21
Fax : 33 (0)4 67 61 37 87
florence.cammas@inserm.fr

PARTENAIRES / FINANCEMENTS


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