Our group is interested in the molecular mechanisms that govern the organization of the genome into chromatin and that lead to cancer. In recent years, we have undertaken the identification and molecular characterization of new signaling pathways in the control of genome activity and organization during the cell cycle. These signaling pathways involve the lysine methyltransferases responsible for the methylation of the lysine 20 at the N-terminal tail of the histone H4. By developing cutting-edge approaches in genomics and proteomics in mammalian and Drosophila models, our current projects aim to (i) better understand how these enzymes and their substrates work and (ii) determine how their inhibition by chemical molecules can lead to innovative therapeutic approaches against cancer.
Team Leader : Eric Julien Institut de Recherche en |
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Tél. : 33 (0)4 67 61 45 14 Fax : 33 (0)4 67 61 37 87 eric.julien@inserm.f |