english
06/06/2019

Required profile.

Expertise in biochemistry, cellular and molecular biology and more specifically in cell culture and study of gene expression (reporter genes, western blot, RT-PCR, RNA-Seq, DNA arrays). The mastery of the culture of the hepatocyte lineage HepaRG would be appreciated.
Skills in use, programming of robotic stations for 96-well, 384-well culture plates, in medium-throughput screening and management of chemical libraries;

Experience in the field of the environment or toxicology (nuclear receptors and more particularly PPARα, PPARγ and PXR, endocrine disruptors, ..);

Ability to work in a team, to manage collaborations with other teams, dynamism and autonomy essential.

 

Recent publications of the team.

 

Riu A, Grimaldi M, le Maire A, Bey G, Phillips K, Boulahtouf A, Perdu E, Zalko D, Bourguet W, Balaguer P. Peroxisome proliferator-activated receptor γ is a target for halogenated analogs of bisphenol A. Environ Health Perspect. 2011; 119: 1227-32.

 

Delfosse V, Grimaldi M, Pons JL, Boulahtouf A, le Maire A, Cavailles V, Labesse G, Bourguet W, Balaguer P. Structural and mechanistic insights into bisphenols action provide guidelines for risk assessment and discovery of bisphenol A substitutes. Proc Natl Acad Sci U S A. 2012; 109: 14930-5.

 

Delfosse V, Grimaldi M, Cavaillès V, Balaguer P, Bourguet W. Structural and functional profiling of environmental ligands for estrogen receptors. Environ Health Perspect. 2014; 122: 1306-13.

 

Grimaldi M, Boulahtouf A, Delfosse V, Thouennon E, Bourguet W, Balaguer P. Reporter cell lines for the characterization of the interactions between human nuclear receptors and endocrine disruptors. Front Endocrinol (Lausanne). 2015 May 11;6:62.

 

Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W. Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds. Nat Commun. 2015. Sep 3;6:8089.

 

Grimaldi M, Boulahtouf A, Toporova L, Balaguer P. Functional profiling of bisphenols for nuclear receptors.Toxicology. 2019 May 15;420:39-45.

 

Thouennon E, Delfosse V, Bailly R, Blanc P, Boulahtouf A, Grimaldi M, Barducci A, Bourguet W, Balaguer P. Insights into the activation mechanism of human estrogen-related receptor γ by environmental endocrine disruptors. Cell Mol Life Sci. 2019. In press.

 

 

Envoyer un CV, une lettre de motivation et lettres de recommandations à / Send a CV, a letter of motivation and letters of recommendation to :

Patrick Balaguer (patrick.balaguer@inserm.fr).


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