from concepts to biomarkers

& innovations in precision medicine

17 research teams,

9 platforms, 3 hosted biotechs

our state-of-the-art tools,

for cancer research

in the heart of a campus dedicated to applied cancer research...

...and Montpellier,

a city historically linked to medical research and teaching

the IRCM research teams
the IRCM research teams

L'Institut de Recherche en Cancérologie de Montpellier :
«Together, let's push the boundaries»

News

SEMINAIRE IRCM

Isabelle ADERCR Inserm,Laboratoire Restore, Equipe MetabolinkUMR 1301 Inserm 5070, CNRS, Université Paul Sabatier (Toulouse) "Multiscale approach to identify health markers related to aging"Aging, is a physiological process often characterized by declining function over time and the primary risk factor for many age-related diseases, impacting health and survival. The World Health Organization (WHO) identifies five key domains to track health during aging, which can reveal frailty as a sign of unhealthy aging and precursor of dependency. Intrinsic capacity (IC) is a metric encompassing these five domains, reflecting the overall physical and mental abilities of an individual, and is now recognized as measurable and predictive of key attributes that support healthy aging. While certain blood biomarkers are linked to frailty syndrome in old individuals, there is a need for one or a set of biomarkers that can predict the risk of frailty in younger individuals. This would allow for the implementation of suitable preventive or intervention strategies to reduce the likelihood or severity of frailty. While IC is associated with comorbidities and frailty, no studies have been conducted to determine whether biomarkers of aging are associated with IC at all ages. The key challenge is to identify correlations between molecular markers and IC, which could improve our understanding of the mechanisms driving functional decline and provide valuable targets for early risk detection and intervention. Despite extensive research, a gap persists in linking systemic and cellular changes to broader aging phenotypes like IC and frailty. In our multiscale study, we aimed to identify functional health markers using samples from the INSPIRE human translational cohort (INSPIRE-T cohort). This cohort included 1000 participants for the plasma study and 133 for the skin fibroblast study, ranging in age from 20 to 96 years, and covering a spectrum of frailty levels (robust, pre-frail, frail) and IC scores. At the systemic scale, plasma samples allowed us to map energy metabolism associated with functional decline and IC, while at the cellular scale, dermal fibroblasts from skin biopsies helped identify health markers, molecular targets, and reveal mechanisms related to aging and IC.?? hôte : Pierre-François Roux (équipe Le Cam), IRCM
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CALL FOR NEW GROUP LEADERS @ IRCM

The IRCM is recruiting new group leaders to establish world-class research programs withinan interactive and supportive scientific environment. Applicants demonstrating potentialsynergies with IRCM’s main research topics will be considered for starting an independentteam as soon as January 2027. Projects at the interface of fundamental and clinical research,particularly those focused on the ICM's flagship pathologies, will be given carefulconsideration. We welcome senior team leaders with permanent INSERM / CNRS positionsas well as early-career researchers eligible to ERC, INSERM ATIP-AVENIR and FRM start-upgrants. MORE INFORMATIONS HERE
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SEMINAIRE EXTERNE IRCM

Raphael J. MorscherPediatric Cancer Metabolism Laboratory, Children's Research Center,University of Zurich, 8032 Zurich, Suisse"Reprogramming neuroblastoma translation by diet-enhanced polyamine depletion"hôte : Alexandre DAVID (IRCM)
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SEMINAIRE IRCM vendredi 29 Novembre 14h

Bassam Janji, PhDGroup Leader, Tumor Immunotherapy and MicroenvironmentLuxembourg Institute of Health, Department of Cancer Research "Breaking the Shield: Innovative Approaches to Overcome the Immunosuppressive Tumor Microenvironment and Improve Cancer Immunotherapy."contact : Andrei Turtoi (IRCM)
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Ingénieur.e d'études en techniques biologiques

Publié le 24/05/2024Mission principale :Dans le cadre de l’étude sur l’épigénétique des neutrophiles, la personne recrutée aura pour principale mission la gestion et l’analyse des prélèvements des patients atteints de cancer du poumon traités à l’ICM ou au CHU. Date de prise de fonction 01.09.2024 Durée (CDD et détachements) CDD : 18 mois Renouvelable En savoir plus ...
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Postdoctoral Position in cell matrix biology & antibody-drug conjugate (IRCM, INSERM U1194, Montpellier, France)

Publié le 22/02/24Application deadline: 31 Mars 2024Anticipated start date: ASAP 2024The team (Breast cancer, Microenvironment and Immunotargeting) at Montpellier Cancer ResearchInstitute (France) is looking for a postdoctoral researcher to work on the optimization of antibodydrugconjugates targeting matricellular proteins in breast cancer. This postdoctoral fellowship is partof a priority research program and equipment (PEPR) ACCREDIA, which brings together a lab networkof seven academic partners funded by the French government to improve knowledge, skills andmethodologies in antibody development. The position is funded in the frame of French PEPR-PIA4Accredia ANR-22-PEBI-0009 for a period of 2 to 3 years.  More
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the word of the director

"Together, let's push the limits."

"In barely 20 years, the Institut de Recherche en Cancérologie de Montpellier (IRCM U1194) has succeeded in raising its research to the highest international level in the field of fundamental and applied cancer research, carried out in close collaboration with the clinical departments of the Montpellier Cancer Center (ICM: l'Institut du Cancer de Montpellier), and industrial partners. Under the joint supervision of Inserm, the ICM and the University of Montpellier, the IRCM brings together more than 240 people, researchers, clinicians, technicians and students, organized in 16 research teams that rely on high-performance technical platforms and competent support services. In an extremely competitive and rapidly evolving field of research, our greatest challenge is to stay one step ahead. To do so, we will continue to structure cancer research in Montpellier, to seek excellence and to accelerate innovation and transfer to the patient in order to ultimately contribute to overcoming the countless different forms of cancer. Together, let's push the limits"

Nathalie Bonnefoy, Director of the IRCM

the word of the director

MAIN PUBLICATIONS

Bousquet Mur E, Bernardo S, Papon L, Mancini M, Fabbrizio E, Goussard M, Ferrer I, Giry A, Quantin X, Pujol J-L, Calvayrac O, Moll H, Glasson Y, Pirot N, Turtoi A, Cañamero M, Wong K-K, Yarden Y, Casanova E, Soria J-C, Colinge J, Siebel C, Favre G, Paz-Ares L, Maraver A Notch inhibition overcomes resistance to Tyrosine Kinase Inhibitors in EGFR-driven lung adenocarcinoma. J. Clin. Invest.. Oct 31, 2019. doi:10.1172/JCI126896

Combes E, Andrade A, Tosi D, Michaud H-A, Coquel F, Desigaud D, Jarlier M, Coquelle A, Pasero P, Bonnefoy N, Martineau P, Del Rio M, Beijersbergen R, Vezzio-Vie N Inhibition of Ataxia-Telangiectasia Mutated and RAD3-related (ATR) overcomes oxaliplatin resistance and promotes anti-tumor immunity in colorectal cancer. Cancer Res.. Apr 15, 2019. doi:10.1158/0008-5472.CAN-18-2807

Ashraf Y, Mansouri H, Laurent-Matha V, Alcaraz L, Roger P, Guiu S, Derocq D, Robin G, Michaud H-A, Jarlier M, Pugnière M, Robert B, Puel A, Martin L, Landomiel F, Bourquard T, Achour O, Fruitier-Arnaudin I, Pichard A, Deshayes E, Turtoi A, Poupon A, Boissière-Michot F, Pirot N, Bernex F, Jacot W, du Manoir S, Theillet C, Pouget J-P, Navarro-Teulon I, Bonnefoy N, Pèlegrin A, Chardès T, Martineau P, Liaudet-Coopman E Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies. J Immunother Cancer. 2019;7(1):29. doi:10.1186/s40425-019-0498-z

Perrot I, Michaud H-A, Giraudon-Paoli M, Augier S, Docquier A, Gros L, Courtois R, Jecko D, Becquart O, Rispaud-Blanc H, Gauthier L, Rossi B, Chanteux S, Gourdin N, Amigues B, Roussel A, Bensussan A, Eliaou J-F, Bastid J, Romagné F, Morel Y, Narni-Mancinelli E, Vivier E, Paturel C, Bonnefoy N Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies. Cell Rep. 2019;27(8):2411-2425.e9. doi:10.1016/j.celrep.2019.04.091

Forest E, Logeay R, Géminard C, Kantar D, Frayssinoux F, Heron-Milhavet L, Djiane A The apical scaffold big bang binds to spectrins and regulates the growth of Drosophila melanogaster wing discs. J. Cell Biol.. 2018;217(3):1047-1062. doi:10.1083/jcb.201705107

Arena G, Cissé M, Pyrdziak S, Chatre L, Riscal R, Fuentes M, Arnold J, Kastner M, Gayte L, Bertrand-Gaday C, Nay K, Angebault-Prouteau C, Murray K, Chabi B, Koechlin-Ramonatxo C, Orsetti B, Vincent C, Marine J-C, Etienne-Manneville S, Bernex F, Lombès A, Cameron C, Dubouchaud H, Ricchetti M, Linares L, Le Cam L Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53. Mol. Cell. 2018;69(4):594-609.e8. doi:10.1016/j.molcel.2018.01.023

Leconet W, Chentouf M, du Manoir S, Chevalier C, Sirvent A, Aït-Arsa I, Busson M, Jarlier M, Radosevic-Robin N, Theillet C, Chalbos D, Pasquet J-M, Pèlegrin A, Larbouret C, Robert B Therapeutic Activity of Anti-AXL Antibody against Triple-Negative Breast Cancer Patient-Derived Xenografts and Metastasis. Clin. Cancer Res.. 2017;23(11):2806-2816. doi:10.1158/1078-0432.CCR-16-1316

Brustel J, Kirstein N, Izard F, Grimaud C, Prorok P, Cayrou C, Schotta G, Abdelsamie A, Déjardin J, Méchali M, Baldacci G, Sardet C, Cadoret J-C, Schepers A, Julien E Histone H4K20 tri-methylation at late-firing origins ensures timely heterochromatin replication. EMBO J.. 2017;36(18):2726-2741. doi:10.15252/embj.201796541


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