Mercredi 6 novembre 2019, 14H, séminaire MabImprove, IRCM



Agency for Science, Technology and Research (A*STAR) à Singapore


"Targeting immunosenescence: the six Ws"


Contact: watier@med.univ-tours.fr



In brief:

Aging is not a disease but is one of the strongest factors associated with diseases such as cancer, cardiovascular, dementia and other chronic conditions leading to loss of autonomy, increased susceptibility to other conditions and a burden to health care systems. As the immune system interacts with most of the physiological systems, it can be used as a surrogate marker of the various organs’ dysfunctions. The study of T cells has shown that their differentiation is highly driven by few dominant stressors (eg. cytomegalovirus) and that accumulation of stressors leads to accumulation of dysfunctional, senescent T cells. Concomitantly, the accumulation of senescent non-immune cells is known to happen altogether leading to a pro-inflammatory state in aging termed inflamm-aging. During this seminar, we will cover those concepts and detail our recent findings on T cell differentiation and senescence. The implication on health in old age (healthspan and diseases) will be discussed as well as potential strategies to reduce the burden of senescent on physiological systems.

Jeudi 14 novembre 2019, 14h, Séminaire IRCM

Muriel Le Romancer-Cherifi


Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR 5286


" Estrogen non genomic signaling in breast cancer"


Contact: charles.theillet@inserm.fr


Vendredi 22 novembre 2019, 14h, Séminaire IRCM

Etienne Gagnon


IRIC, Université de Montréal, Montréal, Qc, Canada


"Next generation chimeric antigen receptors for CAR-T cell therapy: changing speeds, adding gears"


contact: marie-alix.poul@inserm.fr


Vendredi 29 Novembre 2019, 11h, Séminaire IRCM, SIRIC, MabImprove

Charles Dumontet


Centre de Recherche en Cancérologie de Lyon, INSERM U1052, CNRS UMR 5286


"Place actuelle et perspectives de développement des monoclonaux en cancérologie"


Contact: marie-alix.poul@inserm.fr



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