Liste des publications

Ashraf Y*, Mansouri H*, Laurent-Matha V, Alcaraz LB, Roger P, Guiu S, Derocq D, Robin G, Michaud HA, Delpech H, M Jarlier, Pugnière M, Robert B, Puel A, Martin L, Landomiel F, Bourquard T, Achour O, Fruitier-Arnaudin I, Pichard A, Deshayes E, Turtoi A, Poupon A, Simony-Lafontaine J, Boissière-Michot F, Pirot N, Bernex F, Jacot W, Du Manoir S, Theillet C, Pouget JP, Navarro-Teulon I, Bonnefoy N, Pèlegrin A, Chardès T, Martineau P, and Liaudet-Coopman E. Immunotherapy of triple-negative breast cancer with cathepsin-D-targeting antibodies. Journal of ImmunoTherapy of Cancer; 2019, in press.


Guiu S, Mollevi C, Charon-Barra C, Boissière F, Crapez E, Chartron E, Lamy PJ, Gutowski M, Bourgier C, Romieu G, Simony-Lafontaine J, Jacot W. Prognostic value of androgen receptor and FOXA1 co-expression in non-metastatic triple negative breast cancer and correlation with other biomarkers. Br J Cancer. 2018 Jul;119(1):76-79.



Didier R, Mallavialle A, Ben Jouira R, Domdom MA, Tichet M, Auberger P, Luciano F, Ohanna M, Tartare-Deckert S, Deckert M. Targeting the Proteasome-Associated Deubiquitinating Enzyme USP14 Impairs Melanoma Cell Survival and Overcomes Resistance to MAPK-Targeting Therapies. Mol Cancer Ther. 2018 Jul;17(7):1416-1429.



Viala M, Alexandre M, Thezenas S, Lamy PJ, Maran-Gonzalez A, Gutowski M, Colombo PE, Romieu G, Jacot W, Guiu S. Prognostic impact of the inclusion of uPA/PAI-1 for adjuvant treatment decision-making in ER+/Her2- pN0 early breast cancers. Breast Cancer Res Treat. 2017 Oct;165(3):611-621.



Jankowski C, Guiu S, Cortet M, Charon-Barra C, Desmoulins I, Lorgis V, Arnould L, Fumoleau P, Coudert B, Rouzier R, Coutant C, Reyal F. Predictive factors of pathologic complete response of HER2-positive breast cancer after preoperative chemotherapy with trastuzumab: development of a specific predictor and study of its utilities using decision curve analysis. Breast Cancer Res Treat. 2017 Jan;161(1):73-81.



Chuvin N, Vincent DF, Pommier RM, Alcaraz LB, Gout J, Caligaris C, Yacoub K, Cardot V, Roger E, Kaniewski B, Martel S, Cintas C, Goddard-Léon S, Colombe A, Valantin J, Gadot N, Servoz E, Morton J, Goddard I, Couvelard A, Rebours V, Guillermet J, Sansom OJ, Treilleux I, Valcourt U, Sentis S, Dubus P, Bartholin L. Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis. Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):263-282.



Hamouda MA, Jacquel A, Robert G, Puissant A, Richez V, Cassel R, Fenouille N, Roulland S, Gilleron J, Griessinger E, Dubois A, Bailly-Maitre B, Goncalves D, Mallavialle A, Colosetti P, Marchetti S, Amiot M, Gomez-Bougie P, Rochet N, Deckert M, Avet-Loiseau H, Hofman P, Karsenti JM, Jeandel PY, Blin-Wakkach C, Nadel B, Cluzeau T, Anderson KC, Fuzibet JG, Auberger P, Luciano F. BCL-B (BCL2L10) is overexpressed in patients suffering from multiple myeloma (MM) and drives an MM-like disease in transgenic mice.J Exp Med. 2016 Aug 22;213(9):1705-22.



Achour O, Ashraf Y, Bridiau N, Kacem M, Poupard N, Bordenave-Juchereau S, Sannier F, Lamerant-Fayel N, Kieda C, Liaudet-Coopman E, Piot JM, Maugard T, Fruitier-Arnaudin I. Alteration of cathepsin D trafficking induced by hypoxia and extracellular acidification in MCF-7 breast cancer cells. Biochimie. 2016 Feb;121:123-30.



U.Valcourt, J.Carthy, Y.Okita L.B.Alcaraz, M.Kato, S.Thuault, L.Bartholin and A.Moustakas. Analysis of epithelial-mesenchymal transition induced by TGF-b. 2016, Methods in Mol. Biol.1344:147-81.


Régent A, Ly KH, Lofek S, Clary G, Tamby M, Tamas N, Federici C, Broussard C, Chafey P, Liaudet-Coopman E, Humbert M, Perros F, Mouthon L.Proteomic analysis of vascular smooth muscle cells in physiological condition and in pulmonary arterial hypertension: toward contractile versus synthetic phenotypes.  Proteomics. 2016 Jul 25. [Epub ahead of print]


Achour O, Ashraf Y, Bridiau N, Kacem M, Poupard N, Bordenave-Juchereau S, Sannier F, Lamerant- Fayel N, Kieda C, Liaudet-Coopman E, Piot JM, Maugard T, Fruitier-Arnaudin I. Alteration of cathepsin D trafficking induced by hypoxia and extracellular acidification in MCF-7 breast cancer cells. Biochimie. 2015 Nov 12.  [Epub ahead of print]


Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E. Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells. Oncotarget. 2015 Jun 27. [Epub ahead of print].


R.M.Pommier, J.Gout, D.F.Vincent, V.Arfi, L.B.Alcaraz, N.Chuvin,  S.Martel, B.Kaniewski, G.Devailly, G.Fourel, P.Bernard, C.Moyret-Lalle, S.Ansieau, A.Puisieux, U.Valcourt, S.Sentis, and L.Bartholin. TIF1-γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability. 2015, Cancer Research. 75(20):4335-50


U.Valcourt, L.B.Alcaraz, J.Y.Exposito, C.Lethias and L.Bartholin. Tenascin-X: beyond the architectural function. 2015, Cell Adhes.Migr. 9(1-2):154-65.


F.Delolme, C.Anastasi, L.B.Alcaraz*, V.Mendoza, S.Vadon-Le Goff, M. Talantikite, R.Capomaccio, J.Mevaere, L.Fortin, D.Mazzocut, O.Damour, I.Zanella-Cleon, D.J.J.Hulmes, C.M.Overall, U.Valcourt, F.Lopez-Casillas and C.Moali. Proteolytic Control of TGF-b co-receptor activity by BMP-1/tolloid-like Proteases revealed by quantitative iTRAQTM proteomics. 2015, Cell Mol. Life Sci. (*) contribution équivalente. 72(5):1009-27.


L.B.Alcaraz, J.Y.Exposito, N.Chuvin, R.M.Pommier, C.Cluzel, S.MartelL, S.Sentis, L.Bartholin, C.Lethias and U.Valcourt. Tenascin-X promotes epithelial-to mesenchymal transition by activating latent TGF-b. 2014, J. Cell Biol.12;205(3):409-28.


Sebti S1, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S.  BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.  Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4115-20. doi: 10.1073/ pnas. 1313618111. Epub 2014 Mar 3

Laurent-Matha V, Huesgen PF, Masson O, Derocq D, Prébois C, Gary-Bobo M, Lecaille F, Rebière B, Meurice G, Oréar C, Hollingsworth RE, Abrahamson M, Lalmanach G, Overall CM, Liaudet-Coopman E. Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment. FASEB J. 2012 Dec;26(12): 5172-81


Derocq D, Prébois C, Beaujouin M, Laurent-Matha V, Pattingre S, Smith GK, Liaudet-Coopman E. Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis. Oncogene. 2012 Jun 28;31(26): 3202 -12. doi: 10.1038/onc.2011.501.


Masson O, Prébois C, Derocq D, Meulle A, Dray C, Daviaud D, Quilliot D, Valet P, Muller C, Liaudet-Coopman E. Cathepsin-d, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis. PLoS One. 2011 Feb 2;6(2):e16452.


Beaujouin M, Prébois C, Derocq D, Laurent-Matha V, Masson O, Pattingre S, Coopman P, Bettache N, Grossfield J, Hollingsworth RE, Zhang H, Yao Z, Hyman BT, van der Geer P, Smith GK, Liaudet-Coopman E. Pro-cathepsin D interacts with the extracellular domain of the {beta} chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth. J Cell Sci. 2010 Oct 1;123(Pt 19) :3336-46


Masson O, Bach AS, Derocq D, Prébois C, Laurent-Matha V, Pattingre S, Liaudet-Coopman E. Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity? Biochimie. 2010 Nov;92(11):1635-4


Beaujouin M, Baghdiguian S, Glondu-Lassis M, Berchem G, Liaudet-Coopman E. Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity. Oncogene, 2006, 25:1967-73.


Laurent-Matha V, Maruani-Herrmann S, Prebois C, Beaujouin M, Glondu M, Noel A, Alvarez-Gonzalez ML, Blacher S, Coopman P, Baghdiguian S, Gilles C, Loncarek J, Freiss G, Vignon F, Liaudet-Coopman E. Catalytically inactive human cathepsin D triggers fibroblast invasive growth. J. Cell. Biol., 2005, 168:489-499.

Berchem GJ, Glondu M, Gleizes M, Brouillet JP, Vignon F, Garcia M, Liaudet-Coopman E. Cathepsin-D affects multiple steps of tumor progression: Proliferation, angiogenesis and apoptosis. Oncogene, 2002, 21: 5951-5955.

Glondu M, Coopman YP, Laurent-Matha V, Garcia M, Rochefort H, Liaudet-Coopman E. A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells. Oncogene, 2001, 20: 6920-6929.


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