Liste des publications

U.Valcourt, J.Carthy, Y.Okita L.B.Alcaraz, M.Kato, S.Thuault, L.Bartholin and A.Moustakas. Analysis of epithelial-mesenchymal transition induced by TGF-b. 2016, Methods in Mol. Biol.1344:147-81.


Régent A, Ly KH, Lofek S, Clary G, Tamby M, Tamas N, Federici C, Broussard C, Chafey P, Liaudet-Coopman E, Humbert M, Perros F, Mouthon L.Proteomic analysis of vascular smooth muscle cells in physiological condition and in pulmonary arterial hypertension: toward contractile versus synthetic phenotypes.  Proteomics. 2016 Jul 25. [Epub ahead of print]


Achour O, Ashraf Y, Bridiau N, Kacem M, Poupard N, Bordenave-Juchereau S, Sannier F, Lamerant- Fayel N, Kieda C, Liaudet-Coopman E, Piot JM, Maugard T, Fruitier-Arnaudin I. Alteration of cathepsin D trafficking induced by hypoxia and extracellular acidification in MCF-7 breast cancer cells. Biochimie. 2015 Nov 12.  [Epub ahead of print]


Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E. Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells. Oncotarget. 2015 Jun 27. [Epub ahead of print].


R.M.Pommier, J.Gout, D.F.Vincent, V.Arfi, L.B.Alcaraz, N.Chuvin,  S.Martel, B.Kaniewski, G.Devailly, G.Fourel, P.Bernard, C.Moyret-Lalle, S.Ansieau, A.Puisieux, U.Valcourt, S.Sentis, and L.Bartholin. TIF1-γ Suppresses Tumor Progression by Regulating Mitotic Checkpoints and Chromosomal Stability. 2015, Cancer Research. 75(20):4335-50


U.Valcourt, L.B.Alcaraz, J.Y.Exposito, C.Lethias and L.Bartholin. Tenascin-X: beyond the architectural function. 2015, Cell Adhes.Migr. 9(1-2):154-65.


F.Delolme, C.Anastasi, L.B.Alcaraz*, V.Mendoza, S.Vadon-Le Goff, M. Talantikite, R.Capomaccio, J.Mevaere, L.Fortin, D.Mazzocut, O.Damour, I.Zanella-Cleon, D.J.J.Hulmes, C.M.Overall, U.Valcourt, F.Lopez-Casillas and C.Moali. Proteolytic Control of TGF-b co-receptor activity by BMP-1/tolloid-like Proteases revealed by quantitative iTRAQTM proteomics. 2015, Cell Mol. Life Sci. (*) contribution équivalente. 72(5):1009-27.


L.B.Alcaraz, J.Y.Exposito, N.Chuvin, R.M.Pommier, C.Cluzel, S.MartelL, S.Sentis, L.Bartholin, C.Lethias and U.Valcourt. Tenascin-X promotes epithelial-to mesenchymal transition by activating latent TGF-b. 2014, J. Cell Biol.12;205(3):409-28.


Sebti S1, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S.  BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.  Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4115-20. doi: 10.1073/ pnas. 1313618111. Epub 2014 Mar 3

Laurent-Matha V, Huesgen PF, Masson O, Derocq D, Prébois C, Gary-Bobo M, Lecaille F, Rebière B, Meurice G, Oréar C, Hollingsworth RE, Abrahamson M, Lalmanach G, Overall CM, Liaudet-Coopman E. Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment. FASEB J. 2012 Dec;26(12): 5172-81


Derocq D, Prébois C, Beaujouin M, Laurent-Matha V, Pattingre S, Smith GK, Liaudet-Coopman E. Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis. Oncogene. 2012 Jun 28;31(26): 3202 -12. doi: 10.1038/onc.2011.501.


Masson O, Prébois C, Derocq D, Meulle A, Dray C, Daviaud D, Quilliot D, Valet P, Muller C, Liaudet-Coopman E. Cathepsin-d, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis. PLoS One. 2011 Feb 2;6(2):e16452.


Beaujouin M, Prébois C, Derocq D, Laurent-Matha V, Masson O, Pattingre S, Coopman P, Bettache N, Grossfield J, Hollingsworth RE, Zhang H, Yao Z, Hyman BT, van der Geer P, Smith GK, Liaudet-Coopman E. Pro-cathepsin D interacts with the extracellular domain of the {beta} chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth. J Cell Sci. 2010 Oct 1;123(Pt 19) :3336-46


Masson O, Bach AS, Derocq D, Prébois C, Laurent-Matha V, Pattingre S, Liaudet-Coopman E. Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity? Biochimie. 2010 Nov;92(11):1635-4


Beaujouin M, Baghdiguian S, Glondu-Lassis M, Berchem G, Liaudet-Coopman E. Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity. Oncogene, 2006, 25:1967-73.


Laurent-Matha V, Maruani-Herrmann S, Prebois C, Beaujouin M, Glondu M, Noel A, Alvarez-Gonzalez ML, Blacher S, Coopman P, Baghdiguian S, Gilles C, Loncarek J, Freiss G, Vignon F, Liaudet-Coopman E. Catalytically inactive human cathepsin D triggers fibroblast invasive growth. J. Cell. Biol., 2005, 168:489-499.

Berchem GJ, Glondu M, Gleizes M, Brouillet JP, Vignon F, Garcia M, Liaudet-Coopman E. Cathepsin-D affects multiple steps of tumor progression: Proliferation, angiogenesis and apoptosis. Oncogene, 2002, 21: 5951-5955.

Glondu M, Coopman YP, Laurent-Matha V, Garcia M, Rochefort H, Liaudet-Coopman E. A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells. Oncogene, 2001, 20: 6920-6929.


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