Liste des publications

Caucheteur D, Robin G, Parez V, Martineau P. Construction of a Synthetic Antibody Gene Library for the Selection of Intrabodies and Antibodies. Methods Mol Biol. 2018;1701: 239- 253. doi: 10. 1007/978- 1- 4939- 7447-4_12.


Ragulan C, Eason K, Nyamundanda G, Patil Y, Poudel P, Fontana E, Del Rio M, Koo S-L, Tan WS, Martineau P, Cunningham D, Tan I, Sadanandam A. Analytical Validation of Multiplex Biomarker Assay to Stratify Colorectal Cancer Samples into Molecular Subtypes. BioRxiv 2017:174847. doi: 10. 1101/ 174847


Jeitany M, Leroy C, Tosti P, Lafitte M, Le Guet J, Simon V, Bonenfant D, Robert B, Grillet F, Mollevi C, El Messaoudi S, Otandault A, Canterel-Thouennon L, Busson M, Thierry AR, Martineau P, Pannequin J, Roche S, Sirvent A. Inhibition of DDR1-BCR signalling by nilotinib as a new therapeutic strategy for metastatic colorectal cancer. EMBO Mol Med. 2018 Feb 9. pii: e7918 .doi 1015252/emmm.201707918. [Epub ahead of print]


Bourlieu C, Cheillan D, Blot M, Daira P, Trauchessec M, Ruet S, Gassi JY, Beaucher E, Robert B, Leconte N, Bouhallab S, Gaucheron F, Gésan-Guiziou G, Michalski MC. Polar lipid composition of bioactive dairy co-products buttermilk and butterserum : Emphasis on sphingolipid and ceramide isoforms. Food Chem. 2018 Feb 1;240:67-74. doi: 10.1016/ j.foodchem.2017.07.091. Epub 2017 Jul 19.


Courbet A, Bec N, Constant C, Larroque C, Pugniere M, El Messaoudi S, Zghaib Z, Khier S, Deleuze-Masquefa C, Gattacceca F. Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity. PLoS One. 2017 Aug 10;12(8):e0182022. doi: 10.1371/ journal .pone.0182022. eCollection 2017.


Cherradi S, Ayrolles-Torro A, Vezzo-Vié N, Gueguinou N, Denis V, Combes E, Boissière F, Busson M, Canterel-Thouennon L, Mollevi C, Pugnière M, Bibeau F, Ychou M, Martineau P, Gongora C, Del Rio M. Antibody targeting of claudin-1 as a potential colorectal cancer therapy. J Exp Clin Cancer Res. 2017 Jun 28;36(1):89. doi: 10.1186/s13046 -017-0558-5.


Renaud E, Martineau P, Guglielmi L. Solubility Characterization and Imaging of Intrabodies Using GFP-Fusions. Methods Mol Biol. 2017;1575:165-174. doi: 10.1007/978-1-4939-6857-2_9


Del Rio M, Mollevi C, Bibeau F, Vie N, Selves J, Emile JF, Roger P, Gongora C, Robert J, Tubiana-Mathieu N, Ychou M, Martineau P. Molecular subtypes of metastatic colorectal cancer are associated with patient response to irinotecan-based therapies. Eur J Cancer. 2017 Mar 8;76:68-75. doi: 10.1016/j.ejca.2017.02.003. [Epub ahead of print]


Leconet W, Chentouf M, Du Manoir S, Chevalier C, Sirevnt A, Aït-Arsa I, Busson M, Jarlier M, Radosevic - Robin N, Theillet CG, Chalbos D, Pasquet JM, Larbouret C, Pèlegrin A, Robert B. Therapeutic activity of anti-AXL antibody against triple-negative breast cancer Patient Derived Xenografts and metastasis. Clin Cancer Res. 2016 Dec 6. pii: clincanres.1316.2016. [Epub ahead of print]


Zghaib Z, Guichou JF, Vappiani J, Bec N, Hadj-Kaddour K, Vincent LA, Paniagua-Gayraud S, Larroque C, Moarbess G, Cuq P, Kassab I, Deleuze-Masquéfa C, Diab-Assaf M, Bonnet PA. New imidazoquinoxaline derivatives: Synthesis, biological evaluation on melanoma, effect on tubulin polymerization and structure-activity relationships. Bioorg Med Chem. 2016 Apr 1. [Epub ahead of print]


Ribeyre C, Zellweger R, Chauvin M, Bec N, Larroque C, Lopes M, Constantinou A. Nascent DNA Proteomics Reveals a Chromatin Remodeler Required for Topoisomerase I Loading at Replication Forks. Cell Rep. 2016 Mar 30. [Epub ahead of print]


Gioia R, Trégoat C, Dumas PY, Lagarde V, Prouzet-Mauléon V, Desplat V, Sirvent A, Praloran V, Lippert E, Villacreces A, Leconet W, Robert B, Vigon I, Roche S, Mahon FX, Pasquet JM. CBL controls a tyrosine kinase network involving AXL, SYK and LYN in nilotinib-resistant chronic myeloid leukaemia. J Pathol. 2015 Sep;237(1):14-24.  Epub 2015 Jun 4.


Classe JM, Glehen O, Decullier E, Bereder JM, Msika S, Lorimier G, Abboud K, Meeus P, Ferron G, Quenet F, Marchal F, Gouy S, Pomel C, Pocard M, Guyon F, Bakrin N; French Oncologic and Gynecologic HIPEC Group. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for First Relapse of Ovarian Cancer. Anticancer Res. 2015 Sep;35 (9): 4997-5005.


Assenat E, Azria D, Mollevi C, Guimbaud R, Tubiana-Mathieu N, Smith D, Delord JP, Samalin E, Portales F, Larbouret C, Robert B, Bibeau F, Bleuse JP, Crapez E, Ychou M, Pèlegrin A. Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the "THERAPY"phase 1-2 trial. Oncotarget. 2015 May 20;6 (14):12796-808.


Freund G, Desplancq D, Stoessel A, Weinsanto R, Sibler AP, Robin G, Martineau P, Didier P, Wagner J, Weiss E. Generation of an intrabody-based reagent suitable for imaging endogenous proliferating cell nuclear antigen in living cancer cells. J Mol Recognit. 2014 Sep;27(9):549-58. doi: 10.1002/jmr. 2378. PMID: 25042709


Mazuc E, Guglielmi L, Bec N, Parez V, Hahn CS, Mollevi C, Parrinello H, Desvignes JP, Larroque C, Jupp R, Dariavach P, Martineau P. In-cell intrabody selection from a diverse human library identifies c12orf4 protein as a new player in rodent mast cell degranulation. PLoS One. 2014 Aug 14;9(8):e104998. doi: 10.1371/journal.pone.0104998. eCollection 2014. PMID: 25122211


Robin G, Sato Y, Desplancq D, Rochel N, Weiss E, Martineau P. Restricted diversity of antigen binding residues of antibodies revealed by computational alanine scanning of 227 antibody-antigen complexes. J Mol Biol. 2014 Aug 28. pii: S0022-2836(14)00456-2. doi: 10.1016/j.jmb.2014.08.013. [Epub ahead of print] PMID: 25174334


Bianga J, Bouslimani A, Bec N, Quenet F, Mounicou S, Szpunar J, Bouyssiere B, Lobinski R, Larroque C. Complementarity of MALDI and LA ICP mass spectrometry for platinum anticancer imaging in human tumor. Metallomics. 2014 Aug 23;6(8):1382-1386. Epub 2014 Jul 2.


Houédé N, Pourquier P. Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: Its potential use in the treatment of bladder cancers. Pharmacol Ther. 2014 Jun 11. pii: S0163-7258 (14) 00121-1. doi: 10.1016/j.pharmthera. 2014.06.004. [Epub ahead of print]


Del Rio M, Mollevi C, Vezzio-Vie N, Bibeau F, Ychou M, Martineau P. Specific extracellular matrix remodeling signature of colon hepatic metastases. PLoS One. 2013 Sep 4;8(9):e74599. doi: 10. 1371/journal.pone.0074599.


Mazard T, Causse A, Simony J, Leconet W, Vezzio-Vie N, Torro A, Jarlier M, Evrard A, Del Rio M, Assenat E, Martineau P, Ychou M, Robert B, Gongora C Sorafenib overcomes irinotecan resistance in colorectal cancer by inhibiting the ABCG2 drug-efflux pump. Mol Cancer Ther. 2013 Oct;12(10):2121-34. doi: 10.1158/1535-7163.MCT-12-0966. Epub 2013 Aug 19.


Lynne Cassimeris,  Laurence Guglielmi, Vincent Denis, Christian Larroque, Pierre Martineau. Specific In Vivo Labeling of Tyrosinated α-Tubulin and Measurement of Microtubule Dynamics Using a GFP Tagged, Cytoplasmically Expressed Recombinant Antibody. Plos One March 28, 2013


Robin G, Martineau P. Synthetic customized scFv libraries. Methods Mol Biol. 2012;907:109-22. doi: 10.1007/978-1-61779-974-76.


Kamel Deramchia , Marie-Josee Jacobin-Valat, Jeanny Laroche-Traineau, Stephane Bonetto, Stephane Sanchez1 , Pierre Dos Santos , Philippe Massot, Jean-Michel Franconi, Pierre Martineau, Gisele Clofent-Sanchez. By-Passing Large Screening Experiments Using Sequencing as a Tool to Identify scFv Fragments Targeting Atherosclerotic Lesions in a Novel In Vivo Phage Display Selection. Int. J. Mol. Sci. 2012, 13(6), 6902-6923;


Paillas S, Causse A, Marzi L, de Medina P, Poirot M, Denis V, Vezzio-Vie N, Espert L, Arzouk H, Coquelle A, Martineau P, Del Rio M, Pattingre S, Gongora C. MAPK14/p38α confers irinotecan resistance to TP53-defective cells by inducing survival autophagy. Autophagy. 2012 Jul 1;8(7). [Epub ahead of print]

Guglielmi L, Denis V, Vezzio-Vié N, Bec N, Dariavach P, Larroque C, Martineau P. Selection for intrabody solubility in mammalian cells using GFP fusions. Protein Eng Des Sel. 2011 Dec;24(12):873-81.


Villoutreix BO, Laconde G, Lagorce D, Martineau P, Miteva MA, Dariavach P. Tyrosine kinase syk non-enzymatic inhibitors and potential anti-allergic drug-like compounds discovered by virtual and in vitro screening. PLoS One. 2011;6(6):e21117. Epub 2011 Jun 20.


Gongora C, Vezzio-Vie N, Tuduri S, Denis V, Causse A, Auzanneau C, Collod-Beroud G, Coquelle A, Pasero P, Pourquier P, Martineau P, Del Rio M. New Topoisomerase I mutations are associated with resistance to camptothecin. Gongora C, Mol Cancer. 2011 May 27;10(1):64. [Epub ahead of print]


Estephan E, Saab MB, Martin M, Larroque C, Cuisinier FJ, Briot O, Ruffenach S, Moret M, Gergely C. 2010. Phages recognizing the Indium Nitride semiconductor surface via their peptides. J Pept Sci 30: 30


Rogowski K, van Dijk J, Magiera MM, Bosc C, Deloulme JC, Bosson A, Peris L, Gold ND, Lacroix B, Grau MB, Bec N, Larroque C, Desagher S, Holzer M, Andrieux A, Moutin MJ, Janke C.. A family of protein-deglutamylating enzymes associated with neurodegeneration. Cell. 2010;143: 564-578.


Paillas S, Boissiere F, Bibeau F, Denouel A, Mollevi C, Causse A, Denis V, Vezzio-Vie N, Marzi L, Cortijo C, Ait-Arsa I, Askari N, Pourquier P, Martineau P, Del Rio M, Gongora C. 2010. Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma. Cancer Res 2011 Feb 1;71(3):1041-9.


Thierry AR, Mouliere F, Gongora C, Ollier J, Robert B, Ychou M, Del Rio M, Molina F. Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts. Nucleic Acids Res. 2010 Oct;38(18):6159-75


Bonfils C, Bec N, Larroque C, Rio MD, Gongora C, Pugnière M, Martineau P. Cyclophilin A as negative regulator of apoptosis by sequestering cytochrome c.  Biochem Biophys Res Commun. 2010 Mar 5;393(2):325-30.


Amina Bouslimani, Nicole Bec, Matthias Glueckmann, Christophe Hirtz and Christian Larroque. Matrix-assisted laser desorption/ionization imaging mass spectrometry of oxaliplatin derivatives in heated intraoperative chemotherapy (HIPEC)-like treated rat kidney. Rapid Commun. Mass Spectrom. 2010; 24: 415­421


Estephan E, Saab MB, Larroque C, Martin M, Olsson F, Lourdudoss S, Gergely C. Peptides for functionalization of InP semiconductors. J Colloid Interface Sci. 2009 Sep 15;337(2):358-63


Estephan E, Larroque C, Bec N, Martineau P, Cuisinier FJ, Cloitre T, Gergely C. Selection and mass spectrometry characterization of peptides targeting semiconductor surfaces. Biotechnol Bioeng. 2009 Dec 15;104(6):1121-31


Estephan E, Larroque C, Cuisinier FJ, Bálint Z, Gergely C. Tailoring GaN semiconductor surfaces with biomolecules. J Phys Chem B. 2008 Jul 24;112(29):8799-805


Granci V, Bibeau F, Krama A, Boissiere-Michot F,Thezenas S, Thirion A, Gongora C, Martineau P, Del RioM, Ychou M. Prognostic significance of TRAIL-R1 andTRAIL-R3 expression in metastatic colorectal carcinomas. Eur J Cancer 2008; 44: 2312-2318


Mazuc E, Villoutreix BO, Malbec O, Roumier T, Fleury S, Leonetti JP, Dombrowicz D, Daeron M, Martineau P, Dariavach P. A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally.
J Allergy Clin Immunol 2008, 122: 188-194.


Gongora, C., Candeil, L., Vezzio, N., Copois, V., Denis, V., Bareil, C., Molina, F., Fraslon, C., Conseiller, E., Pau, B., Martineau, P., and Del Rio, M. Altered expression of cell proliferation-related and interferon-stimulated genes in colon cancer cells resistant to SN38. Cancer Biol Ther, 7, 2008.


Vie, N., Copois, V., Mollevi, C., Denis, V., Bec, N., Robert, B., Fraslon, C., Conseiller, E., Molina, F., Larroque, C., Martineau, P., Del Rio, M., and Gongora, C. Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells. Mol Cancer, 7: 14, 2008.


Bonfils, C., Bec, N., Lacroix, B., Harricane, M. C., and Larroque, C. Kinetic analysis of tubulin assembly in the presence of the microtubule-associated protein TOGp. J Biol Chem, 282: 5570-5581, 2007.


Copois, V., Bibeau, F., Bascoul-Mollevi, C., Salvetat, N., Chalbos, P., Bareil, C., Candeil, L., Fraslon, C., Conseiller, E., Granci, V., Maziere, P., Kramar, A., Ychou, M., Pau, B., Martineau, P., Molina, F., and Del Rio, M. Impact of RNA degradation on gene expression profiles: assessment of different methods to reliably determine RNA quality. J Biotechnol, 127: 549-559, 2007.


Del Rio, M., Molina, F., Bascoul-Mollevi, C., Copois, V., Bibeau, F., Chalbos, P., Bareil, C., Kramar, A., Salvetat, N., Fraslon, C., Conseiller, E., Granci, V., Leblanc, B., Pau, B., Martineau, P., and Ychou, M. Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan. J Clin Oncol, 25: 773-780, 2007.


Philibert P, Stoessel A, Wang W, Sibler AP, Bec N, Larroque C, Saven JG, Courtete J, Weiss E, Martineau P. A focused antibody library for selecting scFvs expressed at high levels in the cytoplasm. BMC Biotechnol 2007; 7: 81.


 Kramar, A., Gourgou-Bourgade, S., and Ychou, M. Relationship of serum bilirubin to toxicity in patients with metastatic colorectal cancer treated with single-agent high-dose irinotecan. J Clin Oncol, 23: 650; author reply 650-651, 2005.

Philibert, P. and Martineau, P. Directed evolution of single-chain Fv for cytoplasmic expression using the beta-galactosidase complementation assay results in proteins highly susceptible to protease degradation and aggregation. Microb Cell Fact, 3: 16, 2004.

Candeil, L., Gourdier, I., Peyron, D., Vezzio, N., Copois, V., Bibeau, F., Orsetti, B., Scheffer, G. L., Ychou, M., Khan, Q. A., Pommier, Y., Pau, B., Martineau, P., and Del Rio, M. ABCG2 overexpression in colon cancer cells resistant to SN38 and in irinotecan-treated metastases. Int J Cancer, 109: 848-854, 2004.

Sibler, A. P., Nordhammer, A., Masson, M., Martineau, P., Trave, G., and Weiss, E. Nucleocytoplasmic shuttling of antigen in mammalian cells conferred by a soluble versus insoluble single-chain antibody fragment equipped with import/export signals. Exp Cell Res, 286: 276-287, 2003.

Laden, J. C., Philibert, P., Torreilles, F., Pugniere, M., and Martineau, P. Expression and folding of an antibody fragment selected in vivo for high expression levels in Escherichia coli cytoplasm. Res Microbiol, 153: 469-474, 2002.

Gourdier, I., Del Rio, M., Crabbe, L., Candeil, L., Copois, V., Ychou, M., Auffray, C., Martineau, P., Mechti, N., Pommier, Y., and Pau, B. Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma. FEBS Lett, 529: 232-236, 2002.


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