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Riscal R, Gardner S, Coffey N, Carens M, Mesaros C, Xu J, Xue Y, Davis L, Demczyszyn S, Vogt A, Olia A, Finan J, Godfrey J, Schultz D, Blair I, Keith B, Marmorstein R, Skuli N, Simon M Bile Acid Metabolism Mediates Cholesterol Homeostasis and Promotes Tumorigenesis in Clear Cell Renal Cell Carcinoma. 2024;84(10):1570-1582. doi:10.1158/0008-5472.CAN-23-0821
Manteaux G, Amsel A, Riquier-Morcant B, Prieto Romero J, Gayte L, Fourneaux B, Larroque M, Gruel N, Quignot C, Jacq S, Pomiès P, Sengenes C, Chibon F, Heuillet M, Bellvert F, Watson S, Firmin N, Riscal R, Linares L A metabolic crosstalk between liposarcoma and muscle sustains tumor growth. Nat Commun. 2024;15(1):7940. doi:10.1038/s41467-024-51827-3
Decotter J, Desprès P, Gadea G Dengue virus M and E proteins belonging to genotype II (Cosmopolitan) of serotype 2 are influenced by the nature of M residue 36. J Gen Virol. 2023;104(7). doi:10.1099/jgv.0.001872
Reyes-Castellanos G, Abdel Hadi N, Gallardo-Arriaga S, Masoud R, Garcia J, Lac S, El Kaoutari A, Gicquel T, Planque M, Fendt S-M, Linares L, Gayet O, Guillaumond F, Dusetti N, Iovanna J, Carrier A Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo. iScience. 2023;26(6):106899. doi:10.1016/j.isci.2023.106899
Jacquier V, Gitenay D, Fritsch S, Bonnet S, Gy?rffy B, Jalaguier S, Linares L, Cavaillès V, Teyssier C RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53. Cell Mol Life Sci. 2022;79(5):270. doi:10.1007/s00018-022-04277-3
Reslan A, Haddad J, Desprès P, Bascands J-L, Gadea G High Glucose Induces in HK2 Kidney Cells an IFN-Dependent ZIKV Antiviral Status Fueled by Viperin. Biomedicines. 2022;10(7):1577. doi:10.3390/biomedicines10071577
Godfrey J, Riscal R, Skuli N, Simon M Glucagon signaling via supraphysiologic GCGR can reduce cell viability without stimulating gluconeogenic gene expression in liver cancer cells. Cancer Metab. 2022;10(1):4. doi:10.1186/s40170-022-00280-1
Missiaen R, Anderson N, Kim L, Nance B, Burrows M, Skuli N, Carens M, Riscal R, Steensels A, Li F, Simon M GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment. Cell Metab. 2022;34(8):1151-1167.e7. doi:10.1016/j.cmet.2022.06.010
Andries J, Viranaicken W, Cordonin C, Herrscher C, Planesse C, Roquebert B, Lagrange-Xelot M, El-Kalamouni C, Meilhac O, Mavingui P, Couret D, Gadea G Author Correction: The SARS-CoV-2 spike residues 616/644 and 1138/1169 delineate two antibody epitopes in COVID-19 mRNA COMIRNATY vaccine (Pfizer/BioNTech). Sci Rep. 2022;12(1):6498. doi:10.1038/s41598-022-10885-7
Reslan A, Haddad J, Moukendza Koundi L, Desprès P, Bascands J-L, Gadea G Zika Virus Growth in Human Kidney Cells Is Restricted by an Elevated Glucose Level. Int J Mol Sci. 2021;22(5):2495. doi:10.3390/ijms22052495
Lebeau G, Frumence E, Turpin J, Begue F, Hoarau J-J, Gadea G, Krejbich-Trotot P, Desprès P, Viranaicken W Zika E Glycan Loop Region and Guillain-Barré Syndrome-Related Proteins: A Possible Molecular Mimicry to Be Taken in Account for Vaccine Development. Vaccines (Basel). 2021;9(3):283. doi:10.3390/vaccines9030283
Lahalle A, Lacroix M, De Blasio C, Cissé M, Linares L, Le Cam L The p53 Pathway and Metabolism: The Tree That Hides the Forest. Cancers (Basel). 2021;13(1). doi:10.3390/cancers13010133
Lacroix M, Linares L, Rueda-Rincon N, Bloch K, Di Michele M, De Blasio C, Fau C, Gayte L, Blanchet E, Mairal A, Derua R, Cardona F, Beuzelin D, Annicotte J-S, Pirot N, Torro A, Tinahones F, Bernex F, Bertrand-Michel J, Langin D, Fajas L, Swinnen J, Le Cam L The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes. Nat Commun. 2021;12(1):7037. doi:10.1038/s41467-021-27307-3
Stuani L, Sabatier M, Saland E, Cognet G, Poupin N, Bosc C, Castelli F, Gales L, Turtoi E, Montersino C, Farge T, Boet E, Broin N, Larrue C, Baran N, Cissé M, Conti M, Loric S, Kaoma T, Hucteau A, Zavoriti A, Sahal A, Mouchel P-L, Cassan C, Fernando L, Wang F, Hosseini M, Chu-Van E, Le Cam L, Carroll M, Selak M, Vey N, Castellano R, Fenaille F, Turtoi A, Cazals G, Bories P, Gibon Y, Nicolay B, Ronseaux S, Marszalek J, Takahashi K, DiNardo C, Konopleva M, Pancaldi V, Collette Y, Bellvert F, Jourdan F, Linares L, Récher C, Portais J-C, Sarry J-E Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia. J Exp Med. 2021;218(5):e20200924. doi:10.1084/jem.20200924
Xie H, Song J, Godfrey J, Riscal R, Skuli N, Nissim I, Simon M Glycogen metabolism is dispensable for tumour progression in clear cell renal cell carcinoma. Nat Metab. 2021;3(3):327-336. doi:10.1038/s42255-021-00367-x
Riscal R, Bull C, Mesaros C, Finan J, Carens M, Ho E, Xu J, Godfrey J, Brennan P, Johansson M, Purdue M, Chanock S, Mariosa D, Timpson N, Vincent E, Keith B, Blair I, Skuli N, Simon M Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma. Cancer Discov. 2021;11(12):3106-3125. doi:10.1158/2159-8290.CD-21-0211
Arsic N, Slatter T, Gadea G, Villain E, Fournet A, Kazantseva M, Sibille N, Seveno M, de Rossi S, Mehta S, Urbach S, Bourdon J-C, Kajava A, Braithwaite A, Roux P ?133p53? isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells. Nat Commun. 2021;12(1):5463. doi:10.1038/s41467-021-25550-2
Bos S, Seffer V, Manich M, Mardi C, Desprès P, Gadea G, Gougeon M-L Zika Virus Inhibits IFN-? Response by Human Plasmacytoid Dendritic Cells and Induces NS1-Dependent Triggering of CD303 (BDCA-2) Signaling. Front Immunol. 2020;11. doi:10.3389/fimmu.2020.582061
Vanwalscappel B, Haddad J, Almokdad R, Decotter J, Gadea G, Desprès P Zika M Oligopeptide ZAMP Confers Cell Death-Promoting Capability to a Soluble Tumor-Associated Antigen through Caspase-3/7 Activation. Int J Mol Sci. 2020;21(24):9578. doi:10.3390/ijms21249578
Cissé M, Pyrdziak S, Firmin N, Gayte L, Heuillet M, Bellvert F, Fuentes M, Delpech H, Riscal R, Arena G, Chibon F, Le Gellec S, Maran-Gonzalez A, Chateau M-C, Theillet C, Portais J-C, Le Cam L, Linares L Targeting MDM2-dependent serine metabolism as a therapeutic strategy for liposarcoma. Sci Transl Med. 2020;12(547):eaay2163. doi:10.1126/scitranslmed.aay2163
Champagne J, Linares L, Maurel B, Zampieri A, Moreno M, Fuentes I, Dubois E, Severac D, Decorsière A, Bienvenu F TAG-RNAi overcomes off-target effects in cancer models. Oncogene. 2020;39(4):935-945. doi:10.1038/s41388-019-1020-2
Heuillet M, Millard P, Cissé M, Linares L, Létisse F, Manié S, Le Cam L, Portais J-C, Bellvert F Simultaneous Measurement of Metabolite Concentration and Isotope Incorporation by Mass Spectrometry. Anal Chem. 2020;92(8):5890-5896. doi:10.1021/acs.analchem.9b05709
Lacroix M, Riscal R, Arena G, Linares L, Le Cam L Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer. Mol Metab. 2020;33. doi:10.1016/j.molmet.2019.10.002
Li F, Huangyang P, Burrows M, Guo K, Riscal R, Godfrey J, Lee K, Lin N, Lee P, Blair I, Keith B, Li B, Simon M FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome. Nat Cell Biol. 2020;22(6):728-739. doi:10.1038/s41556-020-0511-2
Institut de Recherche en Cancérologie de
